Expression of RA175 mRNA, a new member of the immunoglobulin superfamily, in developing mouse brain

Neuroreport. 2001 Oct 29;12(15):3217-21. doi: 10.1097/00001756-200110290-00015.

Abstract

RA175, a new member of the immunoglobulin superfamily, is highly expressed during neuronal differentiation of P19 embryonal carcinoma cells. In situ hybridization showed that RA175 mRNA was detected in the developing nervous system, as well as the epithelium of the various non-neuronal tissues of mouse embryo. In contrast with the epithelia of the non-neuronal tissues, RA175 mRNA was not co-expressed with Sonic hedgehog mRNA and Patched mRNA during brain morphogenesis. RA175 mRNA was highly expressed in the anterior horn cells and the peripheral nervous system at embryonic day (E) 11.5 and in the central nervous system at E14.5-E18.5, but its expression decreased after birth and was undetectable in the adult mouse brain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / genetics
  • Animals
  • Brain / cytology
  • Brain / embryology*
  • Brain / metabolism
  • Cell Differentiation / physiology*
  • Cell Movement / genetics
  • Cerebellum / cytology
  • Cerebellum / embryology
  • Cerebellum / metabolism
  • Fetus
  • Ganglia, Spinal / cytology
  • Ganglia, Spinal / embryology
  • Ganglia, Spinal / metabolism
  • Gene Expression Regulation, Developmental / physiology*
  • Immunoglobulins / genetics*
  • Mice
  • Mice, Inbred ICR
  • Molecular Sequence Data
  • Neural Cell Adhesion Molecules / genetics*
  • Neurons / cytology
  • Neurons / metabolism*
  • Olfactory Bulb / cytology
  • Olfactory Bulb / embryology
  • Olfactory Bulb / metabolism
  • RNA, Messenger / genetics*
  • Spinal Cord / cytology
  • Spinal Cord / embryology
  • Spinal Cord / metabolism
  • Stem Cells / cytology
  • Stem Cells / metabolism

Substances

  • Immunoglobulins
  • Neural Cell Adhesion Molecules
  • RNA, Messenger

Associated data

  • GENBANK/AB021964
  • GENBANK/AB021965
  • GENBANK/AB021966