GABA(A)-receptor subtypes: a new pharmacology

Curr Opin Pharmacol. 2001 Feb;1(1):22-5. doi: 10.1016/s1471-4892(01)00008-x.

Abstract

The GABA(A) receptor is a pluripotent drug target mediating anxiolytic, sedative, anticonvulsant, muscle relaxant and amnesic activity. These drug actions have now been attributed to defined receptor subtypes. Thus, precise guidelines are available for the development of novel drugs with more selective action and less side effects than those currently in clinical use.

Publication types

  • Review

MeSH terms

  • Amnesia / drug therapy
  • Animals
  • Anti-Anxiety Agents / pharmacology
  • Anticonvulsants / pharmacology
  • Binding Sites / drug effects
  • Humans
  • Hypnotics and Sedatives / pharmacology
  • Muscle Relaxants, Central / pharmacology
  • Receptors, GABA-A / drug effects*
  • Seizures / prevention & control

Substances

  • Anti-Anxiety Agents
  • Anticonvulsants
  • Hypnotics and Sedatives
  • Muscle Relaxants, Central
  • Receptors, GABA-A