Microsatellite allelotyping of chinese nasopharyngeal carcinomas

Anticancer Res. Jul-Aug 2001;21(4B):3081-4.

Abstract

Background: Chinese nasopharyngeal carcinoma (NPC) specimens were analyzed by microsatellite allelotyping to evaluate their usefulness as biomarkers for cancer detection.

Materials and methods: A panel of eight microsatellite markers localized to chromosomes 3p, 6p, 9p, I1q and 14q were used to study 47 specimens.

Results: A moderately low loss of heterozygosity (LOH) frequency (8% to 35%) was observed; 23 (49%) specimens showed LOH with at least one marker while microsatellite instability (MSI) was detected in 10 specimens (21%).

Conclusion: Poor survival was significantly associated with LOH detected by a chromosome 3 marker. Interestingly, tumors with multiple genetic alterations were significanty associated with earlier staging

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alleles*
  • Carcinoma / genetics*
  • Carcinoma / mortality
  • Chromosomes, Human / genetics*
  • Chromosomes, Human, Pair 11 / genetics
  • Chromosomes, Human, Pair 14 / genetics
  • Chromosomes, Human, Pair 3 / genetics
  • Chromosomes, Human, Pair 6 / genetics
  • Chromosomes, Human, Pair 9 / genetics
  • Female
  • Hong Kong / epidemiology
  • Humans
  • Loss of Heterozygosity
  • Male
  • Microsatellite Repeats*
  • Middle Aged
  • Nasopharyngeal Neoplasms / genetics*
  • Nasopharyngeal Neoplasms / mortality
  • Prognosis
  • Survival Analysis