Comparative analysis of age-related changes in activities of monoamine oxidase-B and antioxidant defense enzymes in various structures of human brain

Bull Exp Biol Med. 2001 Aug;132(2):760-2. doi: 10.1023/a:1013081912452.


Activities of monoamine oxidase B, Cu-Zn-dependent superoxide dismutase (SOD), and catalase, and concentration of enzyme-active ceruloplasmin were measured in brain preparations from 43 humans died at the age of 21-92 years. Activity of monoamine oxidase B in the neocortex, cerebellum, basal ganglia, and stem structures increased with age, while SOD activity decreased and catalase and ceruloplasmin concentrations slightly increased. A contribution of age-related increase of cerebral monoamine oxidase activity into ontogenetic impairment of the antioxidant defense in human brain is discussed.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / metabolism*
  • Antioxidants / metabolism*
  • Basal Ganglia / enzymology
  • Brain / enzymology*
  • Brain Stem / enzymology
  • Catalase / metabolism
  • Cerebellum / enzymology
  • Ceruloplasmin / metabolism
  • Female
  • Humans
  • Male
  • Middle Aged
  • Monoamine Oxidase / metabolism*
  • Neocortex / enzymology
  • Superoxide Dismutase / metabolism


  • Antioxidants
  • Catalase
  • Superoxide Dismutase
  • Ceruloplasmin
  • Monoamine Oxidase