Piperacillin/Tazobactam versus cefotaxime plus metronidazole for treatment of children with intra-abdominal infections requiring surgery

Eur J Clin Microbiol Infect Dis. 2001 Sep;20(9):643-6. doi: 10.1007/s100960100581.

Abstract

The efficacy of piperacillin/tazobactam at 100/12.5 mg/kg every 8 h (35 patients) was compared to cefotaxime plus metronidazole at 50/7.5 mg/kg every 8 h (35 patients) in 70 children with intra-abdominal infections requiring surgery. Diagnoses were gangrenous or perforated appendicitis (n =56), peritonitis (n =12), and abscess (n =2). Clinical cure was observed in 35 of 35 evaluable patients treated with piperacilin/tazobactam and in 34 of 34 evaluable patients treated with cefotaxime plus metronidazole. Presumed bacteriological eradication was noted in 29 of 30 evaluable patients in the piperacillin/tazobactam group and in 31 of 31 evaluable patients in the cefotaxime plus metronidazole group. In this study, piperacillin/tazobactam was as effective as cefotaxime plus metronidazole for treating children with intra-abdominal infections requiring surgery.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Abdominal Abscess / drug therapy*
  • Abdominal Abscess / microbiology
  • Abdominal Abscess / surgery
  • Adolescent
  • Appendicitis / drug therapy*
  • Appendicitis / microbiology
  • Appendicitis / surgery
  • Bacterial Infections / drug therapy*
  • Bacterial Infections / microbiology
  • Cefotaxime / administration & dosage
  • Child
  • Child, Preschool
  • Drug Combinations
  • Drug Therapy, Combination / administration & dosage*
  • Female
  • Follow-Up Studies
  • Humans
  • Intestinal Perforation / drug therapy*
  • Intestinal Perforation / microbiology
  • Intestinal Perforation / surgery
  • Male
  • Metronidazole / administration & dosage
  • Microbial Sensitivity Tests
  • Penicillanic Acid / administration & dosage
  • Penicillanic Acid / analogs & derivatives*
  • Peritonitis / drug therapy*
  • Peritonitis / microbiology
  • Peritonitis / surgery
  • Piperacillin / administration & dosage
  • Prospective Studies
  • Tazobactam
  • Treatment Outcome

Substances

  • Drug Combinations
  • Metronidazole
  • Penicillanic Acid
  • Cefotaxime
  • Tazobactam
  • Piperacillin