Susceptibility of pseudomonas aeruginosa to cefepime versus ceftazidime in patients with cystic fibrosis

Pharmacotherapy. 2001 Nov;21(11):1320-4. doi: 10.1592/phco.21.17.1320.34420.


Study objectives: To compare the susceptibility of respiratory cultures of Pseudomonas aeruginosa obtained from patients with cystic fibrosis to cefepime versus ceftazidime. The pattern of cumulative resistance of P aeruginosa to cefepime in patients who had received at least one treatment course of cefepime between two sputum cultures was also characterized.

Design: Prospective consecutive data collection.

Setting: University-affiliated cystic fibrosis clinic and medical center.

Patients: Eighty patients with cystic fibrosis who had at least one sputum culture positive for P aeruginosa with reported microbiologic susceptibilities to cefepime and ceftazidime.

Intervention: Patient data was collected and analyzed. Measurements and Main Results. Two hundred and thirty-one P aeruginosa isolates were collected over 6 months. A total of 16.4% and 8.7% of the isolates were nonsusceptible to cefepime and ceftazidime, respectively (p=0.01). In eight patients who had not received cefepime before the study period, nonsusceptibility was 11.8% and 27.2% before and after exposure to cefepime, respectively.

Conclusions: Susceptibility of P. aeruginosa isolates in patients with cystic fibrosis was lower with cefepime than with ceftazidime. Follow-up surveillance to determine changes in susceptibility of P aeruginosa isolates to cefepime is warranted.

Publication types

  • Comparative Study
  • Multicenter Study

MeSH terms

  • Adolescent
  • Adult
  • Cefepime
  • Ceftazidime / pharmacology*
  • Cephalosporins / pharmacology*
  • Chi-Square Distribution
  • Child
  • Child, Preschool
  • Cystic Fibrosis / drug therapy
  • Cystic Fibrosis / microbiology*
  • Drug Resistance, Bacterial* / physiology
  • Female
  • Humans
  • Infant
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Prospective Studies
  • Pseudomonas aeruginosa / drug effects*
  • Pseudomonas aeruginosa / isolation & purification


  • Cephalosporins
  • Cefepime
  • Ceftazidime