Bagremycin A and B, novel antibiotics from streptomyces sp. Tü 4128

J Antibiot (Tokyo). 2001 Sep;54(9):730-6. doi: 10.7164/antibiotics.54.730.

Abstract

Two novel secondary metabolites, bagremycin A (2) and B (3), were detected in the culture filtrate of Streptomyces sp. Tü 4128 by HPLC-diode-array screening. They are phenol esters of 3-amino-4-hydroxybenzoic acid with a derivative of p-coumaric acid and show a moderate activity against gram-positive bacteria and some fungi.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminobenzoates / chemistry
  • Aminobenzoates / isolation & purification*
  • Aminobenzoates / metabolism
  • Aminobenzoates / pharmacology*
  • Anti-Bacterial Agents / biosynthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology*
  • Chromatography, High Pressure Liquid / methods
  • Fungi / drug effects*
  • Gram-Positive Bacteria / drug effects*
  • Microbial Sensitivity Tests / methods
  • Spectrophotometry, Ultraviolet
  • Streptomyces / classification
  • Streptomyces / growth & development
  • Streptomyces / metabolism*

Substances

  • Aminobenzoates
  • Anti-Bacterial Agents
  • bagremycin A
  • bagremycin B