Men and sin: what's the difference?

Nat Rev Mol Cell Biol. 2001 Nov;2(11):815-26. doi: 10.1038/35099020.


A conserved signalling cascade--termed the mitotic-exit network in budding yeast and the septation-initiation network in fission yeast--controls key events during exit from mitosis and cytokinesis. Although the components of these signalling networks are highly conserved between the two yeasts, the outputs seem quite different. How, then, do these two pathways function, and how are they regulated?

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle
  • Cell Division*
  • Cyclin-Dependent Kinases / physiology
  • Mitosis*
  • Models, Biological
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae / physiology*
  • Signal Transduction


  • Cyclin-Dependent Kinases