Abstract
Aim of our study was to investigate the different effects on attentional capacity of deep brain stimulation DBS (STN or GPi) and of l-dopa in PD patients. Patients were evaluated on-DBS/off-l-dopa, on-l-dopa/off-DBS, on-l-dopa/on-DBS and off-l-dopa/off-DBS. Our results indicate that DBS effects on attentional functions parallel those of l-dopa. A site independent (both STN and GPi) worsening of verbal fluency was observed, possibly connected to the stimulus effect on the cortico-subcortical-cortical loop.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Attention / drug effects
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Attention / physiology*
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Cognition / drug effects
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Cognition / physiology*
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Electric Stimulation Therapy / adverse effects*
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Electric Stimulation Therapy / methods
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Electric Stimulation Therapy / psychology
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Globus Pallidus / drug effects
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Globus Pallidus / physiopathology*
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Humans
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Levodopa / adverse effects*
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Middle Aged
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Neuropsychological Tests
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Parkinson Disease / drug therapy*
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Parkinson Disease / psychology
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Parkinson Disease / surgery*
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Speech Disorders / etiology
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Speech Disorders / physiopathology
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Subthalamic Nucleus / drug effects
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Subthalamic Nucleus / physiopathology*