Integrin signaling revisited

Trends Cell Biol. 2001 Dec;11(12):466-70. doi: 10.1016/s0962-8924(01)02152-3.

Abstract

Adhesion to the extracellular matrix (ECM) is a crucial regulator of cell function, and it is now well established that signaling by integrins mediates many of these effects. Ten years of research has seen integrin signaling advance on many fronts towards a molecular understanding of the control mechanisms. Most striking is the merger with studies of other receptors, the cytoskeleton and mechanical forces within the general field of signaling networks.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Focal Adhesion Kinase 1
  • Focal Adhesion Protein-Tyrosine Kinases
  • Humans
  • Integrins / metabolism*
  • Phosphatidylinositols / metabolism*
  • Protein-Serine-Threonine Kinases / metabolism*
  • Protein-Tyrosine Kinases / metabolism*
  • Signal Transduction / physiology*

Substances

  • Integrins
  • Phosphatidylinositols
  • integrin-linked kinase
  • Protein-Tyrosine Kinases
  • Focal Adhesion Kinase 1
  • Focal Adhesion Protein-Tyrosine Kinases
  • PTK2 protein, human
  • Protein-Serine-Threonine Kinases