Abstract
Using N2 cavitation, we established a protocol to prepare the active mitochondria from Plasmodium falciparum showing a higher succinate dehydrogenase activity than previously reported and a dihydroorotate-dependent respiration. The fact that fumarate partially inhibited the dihydroorotate dependent respiration suggests that complex II (succinate-ubiquinone reductase/quinol-fumarate reductase) in the erythrocytic stage cells of P. falciparum functions as a quinol-fumarate reductase.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Blotting, Western
-
Fumarates / metabolism
-
Mitochondria / enzymology
-
Mitochondria / metabolism*
-
Orotic Acid / analogs & derivatives*
-
Orotic Acid / metabolism*
-
Oxygen / metabolism
-
Oxygen Consumption
-
Plasmodium falciparum / enzymology
-
Plasmodium falciparum / metabolism*
-
Succinate Dehydrogenase / analysis
-
Succinate Dehydrogenase / metabolism*
Substances
-
Fumarates
-
4,5-dihydroorotic acid
-
Orotic Acid
-
fumaric acid
-
Succinate Dehydrogenase
-
Oxygen