Thrombolysis with recombinant tissue plasminogen activator during cardiopulmonary resuscitation in fulminant pulmonary embolism. A case series

Resuscitation. 2001 Oct;51(1):97-101. doi: 10.1016/s0300-9572(01)00384-7.


Objective: To describe our outcomes using thrombolysis during the cardiopulmonary resuscitation (CPR) of patients in cardiorespiratory arrest (CA) caused by fulminant pulmonary embolism (FPE).

Design: A case series.

Setting: Intensive care units of a district hospital and a referral centre.

Patients: Six patients that suffered CA secondary to an FPE.

Interventions: Administration of recombinant tissue plasminogen activator during usual CPR manoeuvres when there was a strong suspicion of FPE. Permission for the thrombolytic therapy was sought from family members in all cases.

Results: Four out of the six patients survived and remain symptom-free. The thrombolysis was not associated with any fatal complications.

Conclusions: Early thrombolysis during CPR manoeuvres for CA apparently caused by an FPE may reduce the mortality rate among these patients.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Cardiopulmonary Resuscitation*
  • Female
  • Fibrinolytic Agents / therapeutic use*
  • Heart Arrest / etiology
  • Heart Arrest / therapy*
  • Humans
  • Male
  • Middle Aged
  • Pulmonary Embolism / complications*
  • Pulmonary Embolism / therapy
  • Thrombolytic Therapy*
  • Tissue Plasminogen Activator / therapeutic use*


  • Fibrinolytic Agents
  • Tissue Plasminogen Activator