Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 21 (5), 303-9

Physiology of IgA and IgA Deficiency

Affiliations
Review

Physiology of IgA and IgA Deficiency

C Cunningham-Rundles. J Clin Immunol.

Abstract

Although secretory immunoglobulin A (IgA) is important in mucosal immunity. selective IgA deficiency is the most common primary immunodeficiency of humans. In most cases this defect is not associated with any illness. The reasons for this are unknown, but other immunological compensations might provide sufficient or complete restitution. Alternatively, it is possible that IgA deficiency alone may not predispose to disease, but additional immunological abnormalities might be present in symptomatic individuals. Some IgA-deficient individuals have a reduced antibody response to immunizations (even with normal IgG and IgM levels) and others have deficient responses to bacterial polysaccharides when IgG subclass levels are normal. The physiological role of IgA, the frequency and causes of IgA deficiency, the diseases associated with its absence, and current limited understanding of the pathogenesis of selective IgA deficiency will be reviewed.

Similar articles

See all similar articles

Cited by 63 PubMed Central articles

See all "Cited by" articles

References

    1. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6901-5 - PubMed
    1. Lancet. 1985 Apr 6;1(8432):778-81 - PubMed
    1. J Exp Med. 1990 Mar 1;171(3):597-613 - PubMed
    1. Immunity. 2000 Oct;13(4):443-51 - PubMed
    1. Clin Immunol Immunopathol. 1995 Aug;76(2):203-8 - PubMed

Substances

LinkOut - more resources

Feedback