Molecular biology of lung cancer

Lung Cancer. 2001 Dec;34 Suppl 2:S35-41. doi: 10.1016/s0169-5002(01)00342-7.


Lung cancer develops slowly over many years from the sequential accumulation of gene alterations in susceptible pulmonary cells. The global epidemic of tobacco addiction has accelerated the incidence of lung cancer and has now focused increased attention on this disease worldwide. This review will briefly outline some of the tumor suppressor gene pathways that are known or suspected to play an important role in the development of this deadly malignancy.

Publication types

  • Review

MeSH terms

  • Carcinoma, Non-Small-Cell Lung / genetics*
  • Carcinoma, Non-Small-Cell Lung / physiopathology*
  • Carcinoma, Small Cell / genetics*
  • Carcinoma, Small Cell / physiopathology*
  • Genes, Tumor Suppressor*
  • Genetic Predisposition to Disease*
  • Humans
  • Incidence
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / physiopathology*
  • Risk Assessment
  • Smoking / adverse effects