Genome structure of Ebola virus subtype Reston: differences among Ebola subtypes. Brief report

Arch Virol. 2001 Oct;146(10):2021-7. doi: 10.1007/s007050170049.


We determined the complete genome sequence of Ebola virus subtype Reston (EBO-R) in the Philippines in 1996. The deduced transcriptional signals were highly conserved among Ebola viruses except for the stop signal of L genes. The intergenic regions were composed of 4 to 7 nucleotides, and of 2 characteristic overlaps and a long intergenic region. The glycoprotein (GP) had several amino acid differences from EBO-R isolated in 1989 and 1992. The variety of GP sequences strongly suggests the independent introduction of EBO-R from unknown natural reservoirs in 1996.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Ebolavirus / classification
  • Ebolavirus / genetics*
  • Genome, Viral*
  • Glycoproteins / chemistry
  • Haplorhini
  • Nucleocapsid Proteins
  • Nucleoproteins*
  • RNA, Viral / chemistry
  • Transcription, Genetic
  • Viral Core Proteins / genetics


  • Glycoproteins
  • Nucleocapsid Proteins
  • Nucleoproteins
  • RNA, Viral
  • Viral Core Proteins