Sarcoma associated with silver coated mechanical heart valve prosthesis

Ann Thorac Surg. 2001 Nov;72(5):1739-40. doi: 10.1016/s0003-4975(01)02578-4.


Sarcomas can develop in association with foreign material (eg, from Dacron vascular prostheses). We report on a left atrial rhabdomyosarcoma that developed within 1 year of mitral valve replacement by a Silzone-coated St. Jude Medical mechanical heart valve. Tumor resection and redo valve replacement were done. Six months later the patient was alive, but an echocardiogram showed tumor recurrence. Although this is a single case, an association between heart valve prostheses and malignant tumors should be considered.

Publication types

  • Case Reports

MeSH terms

  • Coated Materials, Biocompatible
  • Female
  • Heart Atria
  • Heart Neoplasms / etiology*
  • Heart Valve Prosthesis / adverse effects*
  • Humans
  • Middle Aged
  • Prosthesis Design
  • Rhabdomyosarcoma / etiology*
  • Silver


  • Coated Materials, Biocompatible
  • Silver