Seizures in family members of patients with hippocampal sclerosis

Neurology. 2001 Nov 27;57(10):1800-4. doi: 10.1212/wnl.57.10.1800.


Objective: To characterize seizures in family members of patients with refractory temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS).

Methods: The authors systematically investigated family history (FH) of seizures in 66 probands with histologically proven HS, and in 51 control subjects. A positive FH was defined as at least one first-to-third-degree relative being affected. The odds ratio (OR) to be affected with seizures was calculated for siblings, parents, and aunts/uncles.

Results: An FH of seizures was found in 58% of patients, and in 24% of control subjects (p = 0.02). A variety of seizure types were found. Siblings of patients were more likely to be affected than siblings of control subjects (OR 11.5; 95% CI = 1.5 to 86.9 p = 0.003), with febrile convulsions occurring in 5.8% of the siblings of patients. The OR of being affected was 5.7 for parents of patients, and 1.9 for aunts/uncles of patients (p = NS).

Conclusion: FH of seizures, particularly febrile convulsions, are a risk factor for TLE with HS. These data suggest that a variety of genes contributing to epilepsy phenotypes in relatives may be involved in the pathogenesis of HS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Diffuse Cerebral Sclerosis of Schilder / diagnosis
  • Diffuse Cerebral Sclerosis of Schilder / genetics*
  • Diffuse Cerebral Sclerosis of Schilder / surgery
  • Epilepsy, Temporal Lobe / diagnosis
  • Epilepsy, Temporal Lobe / genetics*
  • Epilepsy, Temporal Lobe / surgery
  • Female
  • Genetic Predisposition to Disease / genetics
  • Hippocampus* / pathology
  • Hippocampus* / surgery
  • Humans
  • Male
  • Odds Ratio
  • Phenotype
  • Psychosurgery
  • Risk Factors
  • Seizures, Febrile / diagnosis
  • Seizures, Febrile / genetics
  • Seizures, Febrile / pathology
  • Temporal Lobe / pathology
  • Temporal Lobe / surgery