Mortality of patients with childhood onset (0-17 years) Type I diabetes in Israel: a population-based study

Diabetologia. 2001 Oct;44 Suppl 3:B81-6. doi: 10.1007/pl00002959.

Abstract

Aims/hypothesis: The aim of this study was to examine the mortality rate of subjects with childhood-onset Type I (insulin-dependent) diabetes mellitus in Israel.

Methods: The whole-country cohort of 1,861 children and adolescents (0-17 years) with Type I diabetes, diagnosed between January 1965 and December 1993 in Israel, was analysed for mortality up to October 1996.

Results: A total of 37 deaths were identified with an ascertainment rate of 100%. There was a significant (p < 0.001) excess mortality in the patients with Type I diabetes, the standard mortality ratio being three times higher than that of the general population. The causes of mortality were ketoacidosis (n = 8), infections (n = 8), chronic diabetes complications (n = 9), external causes (n = 6) and other (n = 6). Among the subjects who died, the prevalence of nephropathy, neuropathy and anaemia was higher in female than in male subjects. A total of 17 of the patients with diabetes who died had a central nervous disease (psychosis, mental retardation, epilepsy). There was a trend to lower mortality among the Arab cohort which did not reach statistical significance.

Conclusions/interpretation: Our data provide additional evidence that childhood-onset Type I diabetes carries an increased mortality risk when compared with the mortality risk of the non-diabetic population.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Age of Onset
  • Anemia / mortality
  • Cause of Death
  • Child
  • Child, Preschool
  • Cohort Studies
  • Diabetes Mellitus, Type 1 / mortality*
  • Diabetic Nephropathies / epidemiology
  • Diabetic Nephropathies / mortality
  • Diabetic Neuropathies / epidemiology
  • Diabetic Neuropathies / mortality
  • Female
  • Humans
  • Infant
  • Israel / epidemiology
  • Male
  • Prevalence
  • Registries
  • Sex Characteristics