A behavioural pattern analysis of hypoglutamatergic mice--effects of four different antipsychotic agents

J Neural Transm (Vienna). 2001;108(10):1181-96. doi: 10.1007/s007020170008.


In a hypoglutamatergic rodent model, we have observed certain behaviours that might have relevance for the cognitive impairments seen in autism and schizophrenia. Thus, hypoglutamatergic mice show defective habituation, impaired attention, a meagre behavioural repertoire and a general behavioural primitivization. The aim of the present study was to characterise and quantify changes in movement pattern in mice rendered hypoglutamatergic by means of MK-801 treatment, using an automated video tracking system. Further, the effects of four different antipsychotic drugs, the classical neuroleptic haloperidol, the atypical antipsychotic clozapine, the DA D2/5-HT2A antagonist risperidone and the selective 5-HT2A-receptor antagonist M100907, were compared with respect to effects on NMDA antagonist-induced movement pattern alterations. We found that each receptor antagonist had a unique effect on the MK-801-induced behavioural primitivization. Haloperidol was unable to affect the monotonous behaviour induced by MK-801, while risperidone, clozapine and M100907 produced movement patterns of high intricacy.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antipsychotic Agents / pharmacology*
  • Behavior, Animal / drug effects*
  • Behavior, Animal / physiology*
  • Clozapine / pharmacology
  • Dizocilpine Maleate / pharmacology
  • Dopamine Antagonists / pharmacology
  • Drug Combinations
  • Excitatory Amino Acid Antagonists / pharmacology*
  • Fluorobenzenes / pharmacology
  • Glutamic Acid / deficiency*
  • Haloperidol / pharmacology
  • Injections, Intraperitoneal
  • Male
  • Mice
  • Motor Activity / drug effects
  • Motor Activity / physiology
  • Piperidines / pharmacology
  • Risperidone / pharmacology
  • Serotonin Antagonists / pharmacology


  • Antipsychotic Agents
  • Dopamine Antagonists
  • Drug Combinations
  • Excitatory Amino Acid Antagonists
  • Fluorobenzenes
  • Piperidines
  • Serotonin Antagonists
  • Glutamic Acid
  • Dizocilpine Maleate
  • volinanserin
  • Clozapine
  • Haloperidol
  • Risperidone