Physical growth and retinopathy in preterm infants: involvement of IGF-I and GH

Pediatr Res. 2001 Dec;50(6):732-6. doi: 10.1203/00006450-200112000-00017.


GH and IGF-I are important for physical growth. We measured serum levels of these factors in preterm infants. The study population (n = 81) was divided into three groups according to the gestational age. We evaluated differences in serum GH and IGF-I levels among groups with regard to physical growth and development of retinopathy of prematurity. Serum GH levels in extremely preterm infants born at <28 wk of gestational age were significantly higher than levels in those born between 28 and 34 wk at 1 and 2 mo of age. In contrast, serum IGF-I levels in extremely preterm infants remained low, whereas those in the other two groups gradually increased. Evaluation of the effects of GH and IGF-I on physical growth in very low birth weight infants (<1500 g) showed that IGF-I concentrations were positively related to physical growth for several months after birth, whereas no relationship was observed between GH and physical growth. Multivariate analysis demonstrated that high GH concentration at 1 mo of age was significantly associated with development of severe retinopathy of prematurity. In conclusion, persistent low serum IGF-I levels may explain the slow physical growth during neonatal life, and exposure of high GH may cause, at least in part, severe retinopathy of prematurity in preterm infants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Disease Progression
  • Female
  • Growth / physiology*
  • Human Growth Hormone / blood
  • Human Growth Hormone / physiology*
  • Humans
  • Infant, Newborn
  • Infant, Premature / blood
  • Infant, Premature / growth & development*
  • Insulin-Like Growth Factor I / metabolism
  • Insulin-Like Growth Factor I / physiology*
  • Longitudinal Studies
  • Male
  • Regression Analysis
  • Retinopathy of Prematurity / blood
  • Retinopathy of Prematurity / physiopathology*
  • Risk Factors


  • Human Growth Hormone
  • Insulin-Like Growth Factor I