Renal abnormalities in a population of patients with psoriatic arthritis

Scand J Rheumatol. 2001;30(5):271-4. doi: 10.1080/030097401753180345.

Abstract

Objective: To investigate the prevalence of and to identify predictive factors for renal abnormalities in patients with psoriatic arthritis (PsA).

Methods: 73 patients with PsA were consecutively examined by laboratory analyses and clinically for joint manifestations. Renal function was estimated by creatinine clearance and urinary albumin.

Results: 17 (23.3%) of the patients had renal abnormalities as defined by creatinine clearance below the lower cut off of normal distribution (mean - 2 SD) and/or urinary excretion of albumin more than 25 mg/24 h. These patients were significantly older at the time of the study, older at joint disease onset, had longer skin disease duration, increased serum levels of beta2-microglobulin, and higher incidence of increased ESR and/or CRP levels. Increased ESR/CRP levels had significantly predictive value in multivariate analysis.

Conclusions: In this study subclinical renal abnormalities was a prevalent finding. Predictive factor was inflammatory activity measured by laboratory variables. There were no predisposing effects of NSAID or DMARD therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Albuminuria / etiology
  • Arthritis, Psoriatic / complications*
  • Creatinine / urine
  • Female
  • Humans
  • Kidney Diseases / etiology*
  • Kidney Diseases / pathology
  • Male
  • Middle Aged
  • Prevalence
  • Risk Factors

Substances

  • Creatinine