Thrombotic thrombocytopenic purpura and systemic lupus erythematosus

Scand J Rheumatol. 2001;30(5):308-10. doi: 10.1080/030097401753180417.


Thrombotic thrombocytopenic purpura (TTP) is a rarely seen complicating systemic lupus erythematosus (SLE). The diagnosis of TTP in a setting of SLE is challenging since both share common features including thrombotic microangiopathy. We report two cases of SLE with TTP one with a good response when cyclophosphamide was given early with plasmapheresis and steroids; the other with a poor outcome in a patient given cyclophosphamide late in the course of the disease.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cyclophosphamide / pharmacology*
  • Diagnosis, Differential
  • Female
  • Humans
  • Immunosuppressive Agents / pharmacology*
  • Lupus Erythematosus, Systemic / complications*
  • Lupus Erythematosus, Systemic / pathology
  • Purpura, Thrombotic Thrombocytopenic / drug therapy
  • Purpura, Thrombotic Thrombocytopenic / etiology*
  • Treatment Outcome


  • Immunosuppressive Agents
  • Cyclophosphamide