Abstract
39 patients with active knee osteoarthrosis, chosen according to ACR criteria, were assigned to receive flurbiprofen (n 12, 2 x 100 mg), tiaprofenic acid (n 14, 2 x 300 mg) and placebo (n 13) in a 3-week, placebo-controlled study. All patients completed the study, and both medications were found to be effective: improvement occurred in the clinical signs. These drugs reduced the TNF-alpha levels. Flurbiprofen especially affected the IL-6 levels. Our findings indicate that NSAIDs may be effective in the etiopathogenesis of osteoarthrosis.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Adult
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Aged
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
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Cytokines / blood*
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Female
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Flurbiprofen / therapeutic use*
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Humans
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Interleukin-1 / blood
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Interleukin-6 / blood
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Male
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Middle Aged
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Osteoarthritis, Knee / blood*
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Osteoarthritis, Knee / drug therapy*
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Pain Measurement
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Propionates / therapeutic use*
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Prospective Studies
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Tumor Necrosis Factor-alpha / analysis
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Cytokines
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Interleukin-1
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Interleukin-6
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Propionates
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Tumor Necrosis Factor-alpha
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tiaprofenic acid
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Flurbiprofen