Resistance is futile: assimilation of cellular machinery by HIV-1

Immunity. 2001 Nov;15(5):687-90. doi: 10.1016/s1074-7613(01)00238-2.


HIV-1 budding appears to require Vps4 and Tsg101-two proteins that have links to endosomal sorting machinery. A picture emerges wherein divergent viruses recruit endosomal proteins like Tsg101 to gain access to ubiquitin processes that play a crucial role during viral budding.

Publication types

  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / virology*
  • Adenosine Triphosphatases*
  • Carrier Proteins / physiology*
  • DNA-Binding Proteins / physiology
  • Endosomal Sorting Complexes Required for Transport
  • Endosomes / physiology
  • Fungal Proteins / physiology
  • HIV-1 / physiology*
  • Humans
  • Saccharomyces cerevisiae Proteins*
  • Transcription Factors / physiology
  • Virus Replication


  • Carrier Proteins
  • DNA-Binding Proteins
  • Endosomal Sorting Complexes Required for Transport
  • Fungal Proteins
  • Saccharomyces cerevisiae Proteins
  • Transcription Factors
  • Tsg101 protein
  • VPS4 protein, S cerevisiae
  • Adenosine Triphosphatases