Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion

Immunity. 2001 Nov;15(5):801-12. doi: 10.1016/s1074-7613(01)00236-9.


The interaction between the TNF receptor family member CD27 and its ligand CD70 provides a costimulatory signal for T cell expansion. Normally, tightly regulated expression of CD70 ensures the transient availability of this costimulatory signal. Mice expressing constitutive CD70 on B cells had higher peripheral T cell numbers that showed increased differentiation toward effector-type T cells. B cell numbers in CD70 transgenic (TG) mice progressively decreased in primary and secondary lymphoid organs. This B cell depletion was caused by CD27-induced production of IFNgamma in T cells. We conclude that apart from its role in controlling the size of the activated T cell pool, CD27 ligation contributes to immunity by facilitating effector T cell differentiation.

MeSH terms

  • Animals
  • Antigens, CD*
  • B-Lymphocytes / immunology*
  • CD27 Ligand
  • Immunity, Cellular
  • Interferon-gamma / immunology*
  • Lymphocyte Activation
  • Lymphocyte Cooperation / immunology
  • Lymphocyte Depletion
  • Membrane Proteins / immunology*
  • Mice
  • T-Lymphocytes / immunology*
  • Tumor Necrosis Factor Receptor Superfamily, Member 7 / immunology*


  • Antigens, CD
  • CD27 Ligand
  • Cd70 protein, mouse
  • Membrane Proteins
  • Tumor Necrosis Factor Receptor Superfamily, Member 7
  • Interferon-gamma