Oral contraceptives and stroke in young women. Associated risk factors

JAMA. 1975 Feb 17;231(7):718-22. doi: 10.1001/jama.1975.03240190022010.


Oral contraceptive use alone, in the absence of smoking, hypertension, or migraine, significantly increases the risk of stroke. Regardless of use or nonuse of these agents, hypertension is a risk factor for development of either thrombotic or hemorrhagic stroke. Regular cigarette smoking and a history of symptoms indicative of migraine also increase the likelihood of one or the other type of stroke, but more information is needed before a definite relationship can be established between these clinical factors and cerebrovascular disease.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Black People
  • Carotid Artery Thrombosis / chemically induced
  • Cerebral Hemorrhage / chemically induced
  • Cerebrovascular Disorders / chemically induced*
  • Contraceptives, Oral / adverse effects*
  • Female
  • Humans
  • Hypertension / complications
  • Ischemic Attack, Transient / chemically induced
  • Migraine Disorders / complications
  • Smoking / complications
  • White People


  • Contraceptives, Oral