The ups and downs of MEK kinase interactions

Cell Signal. 2001 Dec;13(12):863-75. doi: 10.1016/s0898-6568(01)00220-0.

Abstract

MEK kinases (MEKKs) comprise a family of related serine-threonine protein kinases that regulate mitogen-activated protein kinase (MAPK) signalling pathways leading to c-Jun NH2-terminal kinase (JNK) and p38 activation, induced by cellular stress (e.g., UV and gamma irradiation, osmotic stress, heat shock, protein synthesis inhibitors), inflammatory cytokines (e.g., tumour necrosis factor alpha, TNFalpha, and interleukin-1, IL1) and G protein-coupled receptor agonists (e.g., thrombin). These stress-activated kinases have been implicated in apoptosis, oncogenic transformation, and inflammatory responses in various cell types. At present, the signalling events involving MEKKs are not well understood. This review summarises our current knowledge concerning the regulation and function of MEKK family members, with particular emphasis on those factors capable of directly interacting with distinct MEKK isoforms.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Cell Movement
  • MAP Kinase Kinase Kinase 2
  • MAP Kinase Kinase Kinase 3
  • MAP Kinase Kinase Kinase 4
  • MAP Kinase Kinase Kinases / chemistry
  • MAP Kinase Kinase Kinases / physiology*
  • MAP Kinase Signaling System*
  • Models, Biological
  • NF-kappa B / metabolism
  • Protein Structure, Tertiary
  • Protein-Serine-Threonine Kinases / chemistry
  • Protein-Serine-Threonine Kinases / physiology
  • Transcriptional Activation

Substances

  • NF-kappa B
  • Protein-Serine-Threonine Kinases
  • MAP Kinase Kinase Kinase 2
  • MAP Kinase Kinase Kinase 3
  • MAP Kinase Kinase Kinase 4
  • MAP Kinase Kinase Kinases