Mapping quantitative trait Loci using generalized estimating equations

Genetics. 2001 Nov;159(3):1325-37. doi: 10.1093/genetics/159.3.1325.

Abstract

A number of statistical methods are now available to map quantitative trait loci (QTL) relative to markers. However, no existing methodology can simultaneously map QTL for multiple nonnormal traits. In this article we rectify this deficiency by developing a QTL-mapping approach based on generalized estimating equations (GEE). Simulation experiments are used to illustrate the application of the GEE-based approach.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Algorithms
  • Chromosome Mapping
  • Computer Simulation
  • Genotype
  • Models, Genetic*
  • Models, Statistical
  • Quantitative Trait, Heritable*