Primitive small round cell tumour of the adrenal gland presenting with fever of unknown origin and t(12;22)(q13;q12) cytogenetic finding

J Clin Pathol. 2001 Dec;54(12):966-9. doi: 10.1136/jcp.54.12.966.


This report describes a left adrenal tumour in a 16 year old Chinese girl who presented with fever of unknown origin. The histological and ultrastructural features of the adrenal tumour were those of a primitive small round cell tumour with neuroendocrine differentiation. Cytogenetic analysis of cultured tumour cells showed a reciprocal translocation t(12;22)(q13;q12). This is the first example of such a tumour being reported in the adrenal gland. The adrenal tumour was also the cause of the fever, which subsided after the removal of the tumour.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Adrenal Gland Neoplasms / complications*
  • Adrenal Gland Neoplasms / genetics
  • Adrenal Gland Neoplasms / pathology
  • Adrenal Medulla / pathology
  • Carcinoma, Small Cell / complications*
  • Carcinoma, Small Cell / genetics
  • Carcinoma, Small Cell / pathology
  • Chromosomes, Human, Pair 12
  • Chromosomes, Human, Pair 22
  • Female
  • Fever / etiology*
  • Fever / genetics
  • Fever / pathology
  • Humans
  • Immunohistochemistry
  • Microscopy, Electron
  • Translocation, Genetic*