The role of trace elements in psoriatic patients undergoing balneotherapy with Dead Sea bath salt

Isr Med Assoc J. 2001 Nov;3(11):828-32.


Background: A beneficial effect was observed in patients with psoriasis vulgaris following balneotherapy with Dead Sea bath salt.

Objectives: To evaluate the possible role of trace elements in the effectiveness of balneotherapy.

Methods: Serum levels of 11 trace elements were analyzed in 23 patients with psoriasis vulgaris who participated in a double-blind controlled study of balneotherapy with either Dead Sea bath salt (12 patients) or common salt (11 patients). Thirteen healthy volunteers served as controls.

Results: The mean pre-treatment serum levels of boron, cadmium, lithium and rubidium were significantly lower in patients compared to controls, whereas the mean pre-treatment serum level of manganese was significantly higher in patients compared to controls. Balneotherapy with Dead Sea bath salt resulted in a significant decrease (P = 0.0051) in the mean serum level of manganese from 0.10 +/- 0.05 mol/L to 0.05 +/- 0.02 mumol/L. The mean reduction in the serum level of manganese differed significantly (P = 0.002) between responders (% Psoriasis Area and Severity Index score reduction > or = 25) and non-responders (% PASI score reduction < 25). Following balneotherapy with Dead Sea bath salt the mean serum level of lithium decreased in responders by 0.01 +/- 0.02 mumol/L, whereas its level in non-responders increased by 0.03 +/- 0.03 mumol/L. (P = 0.015).

Conclusions: Manganese and lithium may play a role in the effectiveness of balneotherapy with Dead Sea bath salt for psoriasis.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Balneology*
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Oceans and Seas
  • Psoriasis / blood
  • Psoriasis / drug therapy*
  • Psoriasis / physiopathology*
  • Severity of Illness Index
  • Skin Absorption / physiology
  • Sodium Chloride / blood
  • Sodium Chloride / therapeutic use
  • Trace Elements / blood
  • Trace Elements / physiology*
  • Trace Elements / therapeutic use*


  • Trace Elements
  • Sodium Chloride