Hypodermoclysis: an alternative infusion technique

Am Fam Physician. 2001 Nov 1;64(9):1575-8.


Hypodermoclysis, the subcutaneous infusion of fluids, is a useful and easy hydration technique suitable for mildly to moderately dehydrated adult patients, especially the elderly. The method is considered safe and does not pose any serious complications. The most frequent adverse effect is mild subcutaneous edema that can be treated by local massage or systemic diuretics. Approximately 3 L can be given in a 24-hour period at two separate sites. Common infusion sites are the chest, abdomen, thighs and upper arms. The preferred solution is normal saline, but other solutions, such as half-normal saline, glucose with saline or 5 percent glucose, can also be used. Potassium chloride can be added to the solution bag if needed. Hyaluronidase can also be added to enhance fluid absorption. Hypodermoclysis can be administered at home by family members or a nurse; the technique should be familiar to every family physician.

Publication types

  • Review

MeSH terms

  • Aged
  • Fluid Therapy / adverse effects
  • Fluid Therapy / methods*
  • Glucose / administration & dosage
  • Humans
  • Hyaluronoglucosaminidase / administration & dosage
  • Infusions, Intravenous
  • Sodium Chloride / administration & dosage


  • Sodium Chloride
  • Hyaluronoglucosaminidase
  • Glucose