From progesterone to active Cdc2 in Xenopus oocytes: a puzzling signalling pathway

Biol Cell. 2001 Sep;93(1-2):35-46. doi: 10.1016/s0248-4900(01)01126-1.


Since almost two decades, it is known that progesterone is responsible of the release of the prophase I arrest of amphibian oocytes and leads to the activation of the universal MPF, through a puzzling transduction pathway. It involves negative regulation of the cAMP-dependent protein kinase (PKA) and synthesis of new proteins, among them the c-Mos protooncogene product. The implication of the Mos/mitogenic activated protein kinase (MAP kinase) pathway in Cdc2 activation has been extensively studied and is now at the centre of a controversial debate. In this paper, we discuss the current progress and our recent results on the molecular mechanisms allowing progesterone to activate MPF and propose a model to partly resolve the long-standing inconsistencies concerning the role of Mos/MAP kinase during this process.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CDC2 Protein Kinase / metabolism*
  • Cell Cycle Proteins / physiology
  • Cyclins / physiology
  • Enzyme Activation
  • Genes, mos / physiology
  • Humans
  • Maturation-Promoting Factor / physiology
  • Meiosis / physiology
  • Mitogen-Activated Protein Kinases / physiology
  • Monomeric GTP-Binding Proteins / physiology
  • Oocytes / physiology*
  • Progesterone / metabolism*
  • Signal Transduction
  • Xenopus
  • Xenopus Proteins*


  • Cell Cycle Proteins
  • Cyclins
  • SPDYA protein, human
  • Xenopus Proteins
  • ls27 protein, Xenopus
  • Progesterone
  • CDC2 Protein Kinase
  • Maturation-Promoting Factor
  • Mitogen-Activated Protein Kinases
  • Monomeric GTP-Binding Proteins