IL-7-enhanced T-cell response to myelin proteins in multiple sclerosis

J Neuroimmunol. 2001 Dec 3;121(1-2):111-9. doi: 10.1016/s0165-5728(01)00433-7.


In this study, we investigated the in vitro proliferative response of peripheral blood T lymphocytes from MS patients and controls to MBP and MOG either in the absence or in the presence of the conditioning factor IL-7. In the absence of IL-7, T-cell reactivity to MOG and MBP was similar in MS patients and controls even if an increased MBP response was found in a subgroup of patients with active disease. In the presence of IL-7, increased T-cell reactivity to MBP was observed in MS patients suggesting that their MBP-specific T cells are in a different functional state.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • In Vitro Techniques
  • Interleukin-7 / pharmacology*
  • Male
  • Middle Aged
  • Multiple Sclerosis, Chronic Progressive / immunology*
  • Multiple Sclerosis, Relapsing-Remitting / immunology*
  • Myelin Basic Protein / immunology
  • Myelin Basic Protein / pharmacology*
  • Myelin Proteins
  • Myelin-Associated Glycoprotein / immunology
  • Myelin-Associated Glycoprotein / pharmacology*
  • Myelin-Oligodendrocyte Glycoprotein
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology*


  • Interleukin-7
  • MOG protein, human
  • Myelin Basic Protein
  • Myelin Proteins
  • Myelin-Associated Glycoprotein
  • Myelin-Oligodendrocyte Glycoprotein