Increase of tyrosine hydroxylase and dopamine transporter mRNA levels in ventral tegmental area of male mice under influence of repeated aggression experience

M L Filipenko; O V Alekseyenko; A G Beilina; T P Kamynina; N N Kudryavtseva

doi:10.1016/s0169-328x(01)00270-4

Increase of tyrosine hydroxylase and dopamine transporter mRNA levels in ventral tegmental area of male mice under influence of repeated aggression experience

Brain Res Mol Brain Res. 2001 Nov 30;96(1-2):77-81. doi: 10.1016/s0169-328x(01)00270-4.

Authors

M L Filipenko¹, O V Alekseyenko, A G Beilina, T P Kamynina, N N Kudryavtseva

Affiliation

¹ Institute of Bioorganic Chemistry SD RAS, Pr. Lavrentieva, 8, 630090, Novosibirsk, Russia. max@niboch.nsc.ru

PMID: 11731011
DOI: 10.1016/s0169-328x(01)00270-4

Abstract

Tyrosine hydroxylase (TH) and dopamine transporter (DAT) mRNA levels in the ventral tegmental area (VTA) of midbrain were measured by multiplex RT-PCR in male mice with repeated experience of social victories (winners) and social defeats (losers) in 10 daily agonistic confrontations. Two independent experiments revealed enhanced TH and DAT mRNA levels in VTA of the winners in comparison with the losers and controls (animals after 5 days of individual housing). A positive correlation between DAT and TH mRNA levels was shown.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aggression / physiology*
Animals
Dopamine Plasma Membrane Transport Proteins
Gene Expression / physiology
Male
Membrane Glycoproteins*
Membrane Transport Proteins / genetics*
Mice
Mice, Inbred CBA
Nerve Tissue Proteins*
RNA, Messenger / metabolism
Reverse Transcriptase Polymerase Chain Reaction
Stress, Psychological / physiopathology
Tyrosine 3-Monooxygenase / genetics*
Ventral Tegmental Area / physiology*

Substances

Dopamine Plasma Membrane Transport Proteins
Membrane Glycoproteins
Membrane Transport Proteins
Nerve Tissue Proteins
RNA, Messenger
Slc6a3 protein, mouse
Tyrosine 3-Monooxygenase