Intolerance to neuroleptics and susceptibility for malignant hyperthermia in a patient with proximal myotonic myopathy (PROMM) and schizophrenia

Neuromuscul Disord. 2002 Jan;12(1):31-5. doi: 10.1016/s0960-8966(01)00238-3.


We report a patient with proximal myotonic myopathy who was treated with neuroleptics because of exacerbating schizophrenia. Under therapy with fluanxol, the patient developed muscle stiffness and oculogyric cramps. Treatment with both amisulpride and olanzapine lead to markedly elevated serum creatine kinase levels. An in-vitro contracture test was positive for halothane. Thus, in patients with all kinds of multisystemic myotonic myopathies, a susceptibility for malignant hyperthermia and intolerance towards neuroleptics should be taken into account.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antipsychotic Agents / adverse effects*
  • Biopsy
  • Event-Related Potentials, P300
  • Flupenthixol / adverse effects*
  • Humans
  • Male
  • Malignant Hyperthermia / etiology*
  • Muscle, Skeletal / pathology
  • Myotonic Disorders / complications*
  • Myotonic Disorders / pathology
  • Schizophrenia / complications*
  • Schizophrenia / drug therapy*


  • Antipsychotic Agents
  • Flupenthixol