Septum formation in Aspergillus nidulans

Curr Opin Microbiol. 2001 Dec;4(6):736-9. doi: 10.1016/s1369-5274(01)00276-4.


Filamentous fungi form multicellular hyphae that are partitioned by septa. In A. nidulans, septum formation requires the assembly of a septal band following the completion of mitosis. Recent observations show that this band is a dynamic structure composed of actin, a septin and a formin. In addition, assembly is dependent upon a conserved protein kinase cascade that regulates mitotic exit and septation in yeast. Hyphal differentiation may reflect the regulation of this cascade by cyclin-dependent kinase activity. In this review, the dynamics and regulation underlying the assembly of the septal band are discussed.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Aspergillus nidulans / genetics
  • Aspergillus nidulans / physiology*
  • Cell Division / physiology
  • Cyclin-Dependent Kinases / metabolism


  • Cyclin-Dependent Kinases