T Cells Down-Modulate peptide-MHC Complexes on APCs in Vivo

Nat Immunol. 2002 Jan;3(1):27-32. doi: 10.1038/ni742. Epub 2001 Dec 3.

Abstract

T cells compete in the response to antigen in vivo and this competition may drive the affinity maturation of a secondary T cell response. Here we show that high-affinity T cells out-competed lower affinity T cells during a response to antigenic challenge in vivo. Although competition between T cells specific for different peptide-major histocompatibility complexes (MHC) occurred, it was less efficient than competition between T cells of the same peptide-MHC specificity. In addition, high-affinity T cells efficiently induced antigen loss from the surface of antigen-presenting cells. Thus T cells that responded to the same peptide-MHC competed with each other by lowering the amount of ligand with which the cells could react. As a result, the activation of high-affinity cells was favored. This provides a mechanism for the affinity maturation of a secondary T cell response.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adoptive Transfer
  • Animals
  • Antigen Presentation*
  • Antigens / immunology*
  • Antigens / metabolism
  • Antigens, Viral / immunology*
  • Binding, Competitive
  • Cell Membrane / immunology*
  • Cell Membrane / metabolism
  • Clone Cells / immunology
  • Cytotoxicity, Immunologic*
  • Dendritic Cells / immunology
  • Dendritic Cells / metabolism
  • Egg Proteins / immunology*
  • Gene Rearrangement, T-Lymphocyte*
  • Glycoproteins / immunology*
  • H-2 Antigens / immunology*
  • Histocompatibility Antigen H-2D
  • Immunologic Memory
  • Lymphocyte Count
  • Macromolecular Substances
  • Mice
  • Mice, Inbred C57BL
  • Oligopeptides / immunology*
  • Ovalbumin / immunology*
  • Peptide Fragments / immunology*
  • Receptors, Antigen, T-Cell / genetics
  • Receptors, Antigen, T-Cell / immunology*
  • Receptors, Antigen, T-Cell / metabolism
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / metabolism
  • T-Lymphocytes / transplantation
  • Viral Proteins / immunology*

Substances

  • Antigens
  • Antigens, Viral
  • Egg Proteins
  • Glycoproteins
  • H-2 Antigens
  • H-2Kb protein, mouse
  • Histocompatibility Antigen H-2D
  • Macromolecular Substances
  • OVA-8
  • Oligopeptides
  • Peptide Fragments
  • Receptors, Antigen, T-Cell
  • Viral Proteins
  • glycoprotein peptide 33-41, Lymphocytic choriomeningitis virus
  • superagonist SIYR
  • Ovalbumin