Inhibitory effect of magnolol and honokiol from Magnolia obovata on human fibrosarcoma HT-1080. Invasiveness in vitro

Planta Med. 2001 Nov;67(8):705-8. doi: 10.1055/s-2001-18345.


We investigated the inhibitory effect of Magnolia obovata Thunb. bark ethanol extracts on human fibrosarcoma HT-1080 cells invasion in a reconstituted basement membrane [Matrigel (MG)]. We found that the effective components of the bark ethanol extracts were magnolol and honokiol, two biphenyl compounds. The extracts, magnolol and honokiol, did not affect HT-1080 cells adhesion to MG, but did inhibit HT-1080 cells migration at a high concentration (100 microM). HT-1080 cells secrete matrix metalloproteinase (MMP)-9, which degrades the extracellular matrix as a part of the invasive process. Magnolol and honokiol inhibited the activity of MMP-9, which may have been responsible, in part, for the inhibition of tumor cell invasiveness.

MeSH terms

  • Antineoplastic Agents, Phytogenic / therapeutic use*
  • Biphenyl Compounds / chemistry
  • Biphenyl Compounds / therapeutic use*
  • Fibrosarcoma / drug therapy*
  • Humans
  • Lignans*
  • Magnoliaceae* / chemistry
  • Matrix Metalloproteinase Inhibitors
  • Neoplasm Invasiveness
  • Phytotherapy
  • Plant Bark / chemistry
  • Tumor Cells, Cultured


  • Antineoplastic Agents, Phytogenic
  • Biphenyl Compounds
  • Lignans
  • Matrix Metalloproteinase Inhibitors
  • magnolol
  • honokiol