Cloning and characterization of a novel human transcription factor AP-2 beta like gene (TFAP2BL1)

Int J Biochem Cell Biol. 2002 Jan;34(1):78-86. doi: 10.1016/s1357-2725(01)00098-x.


The AP-2 transcription factor has been shown to play an important role in development, morphogenesis, apoptosis, cell-cycle control and has also been implicated in mammary oncogenesis. Here we report the cloning and characterization of a novel human transcription factor AP-2 like gene (TFAP2BL1), which is located on human chromosome 6p12.1-21.1. The TFAP2BL1 cDNA is 2076 base pairs in length, encoding a 452-amino acid polypeptide related to human Ap-2protein. TFAP2BL1 gene has significantly high homology to transcription factor AP-2 gene of human, mouse, chicken, sheep, fruit fly, and C. elegans at amino acid level. RT-PCR analysis shows its relatively high expression level in adult thymus, prostate, small intestine, skeletal muscle, placenta, brain, and testis tissues.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 6 / genetics
  • Cloning, Molecular
  • DNA, Complementary / genetics
  • DNA-Binding Proteins / genetics*
  • Female
  • Gene Expression
  • Humans
  • Male
  • Molecular Sequence Data
  • Pregnancy
  • Sequence Homology, Amino Acid
  • Species Specificity
  • Tissue Distribution
  • Transcription Factor AP-2
  • Transcription Factors / genetics*


  • DNA, Complementary
  • DNA-Binding Proteins
  • TFAP2B protein, human
  • TFAP2D protein, human
  • Transcription Factor AP-2
  • Transcription Factors

Associated data

  • GENBANK/AF028376