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. 2001 Nov 16;12(16):3549-52.
doi: 10.1097/00001756-200111160-00035.

Excessive Sugar Intake Alters Binding to Dopamine and Mu-Opioid Receptors in the Brain

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Excessive Sugar Intake Alters Binding to Dopamine and Mu-Opioid Receptors in the Brain

C Colantuoni et al. Neuroreport. .

Abstract

Palatable food stimulates neural systems implicated in drug dependence; thus sugar might have effects like a drug of abuse. Rats were given 25% glucose solution with chow for 12 h followed by 12 h of food deprivation each day. They doubled their glucose intake in 10 days and developed a pattern of excessive intake in the first hour of daily access. After 30 days, receptor binding was compared to chow-fed controls. Dopamine D-1 receptor binding increased significantly in the accumbens core and shell. In contrast, D-2 binding decreased in the dorsal striatum. Binding to dopamine transporter increased in the midbrain. Opioid mu-1 receptor binding increased significantly in the cingulate cortex, hippocampus, locus coeruleus and accumbens shell. Thus, intermittent, excessive sugar intake sensitized D-1 and mu-1 receptors much like some drugs of abuse.

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