Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 2 (12), 943-55

Genetics of Autism: Complex Aetiology for a Heterogeneous Disorder


Genetics of Autism: Complex Aetiology for a Heterogeneous Disorder

S E Folstein et al. Nat Rev Genet.


Since autism was first recognized as a disorder in 1943, speculation about its aetiology has ranged from biological to psychological and back again. After twin studies during the 1970s and 1980s yielded unequivocal evidence for a genetic component, aetiological research in autism began to focus primarily on uncovering the genetic mechanisms involved. The identification of chromosomal abnormalities and Mendelian syndromes among individuals with autism, in conjunction with data from genome screens and candidate-gene studies, has helped to refine the view of the complex genetics that underlies autism spectrum conditions.

Similar articles

  • Autism: The Quest for the Genes
    NH Sykes et al. Expert Rev Mol Med 9 (24), 1-15. PMID 17764594. - Review
    Autism, at its most extreme, is a severe neurodevelopmental disorder, and recent studies have indicated that autism spectrum disorders are considerably more common than p …
  • Chromosomal Anomalies in Individuals With Autism: A Strategy Towards the Identification of Genes Involved in Autism
    D Castermans et al. Autism 8 (2), 141-61. PMID 15165431. - Review
    We review the different strategies currently used to try to identify susceptibility genes for idiopathic autism. Although identification of genes is usually straightforwa …
  • Autism: An Overview of Genetic Aetiology
    N Bayou et al. Tunis Med 86 (6), 573-8. PMID 19216451. - Review
    Autism is a pervasive developmental disorder characterised by impairment in social interaction and in communication, with unusual behaviour. Genetic factors are predomina …
  • [Genetics of Autism]
    Z Sedlácek et al. Cas Lek Cesk 141 (12), 376-80. PMID 12238023. - Review
    Autism is a severe psychiatric disorder characterised by deficits in social interaction, disturbed communication and adherence to stereotype routines and interests. Nowad …
  • Molecular Genetics of Autism Spectrum Disorders
    BS Shastry. J Hum Genet 48 (10), 495-501. PMID 13680297. - Review
    Autistic disorder belongs to a broad spectrum of pervasive developmental disorders. Autism is a clinically and genetically heterogeneous condition. It is characterized by …
See all similar articles

Cited by 212 PubMed Central articles

See all "Cited by" articles

LinkOut - more resources