CHK2 kinase--a busy messenger

Nat Rev Mol Cell Biol. 2001 Dec;2(12):877-86. doi: 10.1038/35103059.

Abstract

Checkpoint kinase 2 (Chk2) is emerging as a key mediator of diverse cellular responses to genotoxic stress, guarding the integrity of the genome throughout eukaryotic evolution. Recent studies show the fundamental role of Chk2 in the network of genome-surveillance pathways that coordinate cell-cycle progression with DNA repair and cell survival or death. Defects in Chk2 contribute to the development of both hereditary and sporadic human cancers, and earmark this kinase as a candidate tumour suppressor and an attractive target for drug discovery.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Evolution
  • Cell Cycle
  • Checkpoint Kinase 2
  • Drug Design
  • Enzyme Activation
  • Enzyme Inhibitors / pharmacology
  • Genes, Tumor Suppressor
  • Humans
  • Models, Biological
  • Mutation
  • Neoplasms / genetics
  • Protein Kinases / chemistry
  • Protein Kinases / genetics
  • Protein Kinases / physiology*
  • Protein-Serine-Threonine Kinases*
  • Signal Transduction

Substances

  • Enzyme Inhibitors
  • Protein Kinases
  • Checkpoint Kinase 2
  • CHEK2 protein, human
  • Protein-Serine-Threonine Kinases