The role of Fas ligand in immune privilege

Nat Rev Mol Cell Biol. 2001 Dec;2(12):917-24. doi: 10.1038/35103104.


Immune privilege is a property of some sites in the body, whereby immune responses are limited or prevented. One explanation that has been proposed for this phenomenon is engagement of the pro-apoptotic molecule Fas by its ligand (FasL), which leads to apoptosis, and consequently limits an inflammatory response. This idea has recently been challenged, and here we review the evidence for and against a role for FasL in immune privilege.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / immunology
  • Eye / cytology
  • Eye / immunology
  • Fas Ligand Protein
  • Graft Survival
  • Humans
  • Immune Tolerance
  • Inflammation / etiology
  • Inflammation / immunology
  • Male
  • Membrane Glycoproteins / immunology*
  • Models, Immunological*
  • Neoplasms / immunology
  • Transplantation, Homologous
  • fas Receptor / physiology


  • FASLG protein, human
  • Fas Ligand Protein
  • Membrane Glycoproteins
  • fas Receptor