Burkholderia cepacia complex genomovars and pulmonary transplantation outcomes in patients with cystic fibrosis

Lancet. 2001 Nov 24;358(9295):1780-1. doi: 10.1016/S0140-6736(01)06808-8.


Burkholderia cepacia is a group of organisms that comprises seven genotypically distinct species (B cepacia genomovars I-VII), which are collectively known as the B cepacia complex. Preoperative infection with B cepacia is associated with a poor prognosis in lung transplant recipients with cystic fibrosis. Many centres do not, therefore, offer transplants to these individuals. Our aim was to ascertain whether or not post-transplant mortality is affected by pretransplant genomovar status. We studied archived isolates with PCR-based methods, and recorded excessive mortality in patients infected with B cepacia genomovar III, but not in those infected with other genomovars.

Publication types

  • Letter

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Burkholderia Infections / complications*
  • Burkholderia Infections / drug therapy
  • Burkholderia cepacia / genetics*
  • C-Reactive Protein / metabolism
  • Cystic Fibrosis / complications*
  • Cystic Fibrosis / mortality
  • Cystic Fibrosis / surgery
  • Databases, Factual
  • Drug Resistance, Multiple, Bacterial
  • Humans
  • Lung Transplantation*
  • Prognosis
  • Survival Rate


  • Anti-Bacterial Agents
  • C-Reactive Protein