Enhancement of tumorigenic, metastatic and in vitro invasive capacity of rat mammary tumor cells by transforming growth factor-beta

Cancer Lett. 2002 Jan 10;175(1):95-106. doi: 10.1016/s0304-3835(01)00728-5.


We investigated the effects of transforming growth factor-beta (TGF-beta) on biological behavior of a weakly malignant rat mammary carcinoma ER-1 cell line. TGF-beta enhanced the tumorigenic and metastatic capacity of ER-1 cells and their in vitro invasiveness to rat mesothelial and endothelial cell. Further cell biological analysis indicated that the increased invasive and metastatic capacity of ER-1 cells by TGF-beta was due to the increase in cell motility and adhesion to the mesothelial and endothelial cell monolayers. Thus, it is suggested that TGF-beta acts on ER-1 cells as a progression-enhancing factor which stimulates their adhesive and motile activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies / pharmacology
  • Cell Adhesion / drug effects
  • Cell Adhesion Molecules / genetics
  • Cell Movement / drug effects
  • Chemotaxis / drug effects
  • DNA-Binding Proteins
  • Dose-Response Relationship, Drug
  • Female
  • Hyaluronan Receptors / immunology
  • Hyaluronic Acid / pharmacology
  • Hyaluronoglucosaminidase / pharmacology
  • Immediate-Early Proteins / genetics
  • Kinetics
  • Mammary Neoplasms, Experimental / pathology*
  • Mice
  • Neoplasm Invasiveness
  • Neoplasm Metastasis / pathology*
  • Nuclear Proteins / genetics
  • Trans-Activators / genetics
  • Transforming Growth Factor beta / pharmacology*
  • Xenopus Proteins*


  • Antibodies
  • Cell Adhesion Molecules
  • DNA-Binding Proteins
  • Hyaluronan Receptors
  • Immediate-Early Proteins
  • MIER1 protein, Xenopus
  • Nuclear Proteins
  • Trans-Activators
  • Transforming Growth Factor beta
  • Xenopus Proteins
  • Hyaluronic Acid
  • Hyaluronoglucosaminidase