Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 44 (6), 541-5

Nefopam Reduces Thermal Hypersensitivity in Acute and Postoperative Pain Models in the Rat

Affiliations

Nefopam Reduces Thermal Hypersensitivity in Acute and Postoperative Pain Models in the Rat

P Girard et al. Pharmacol Res.

Abstract

The activity of nefopam, a centrally acting compound, not structurally related to other analgesics, was examined in acute and postoperative thermal pain models in the rat. Its antinociceptive potency was evaluated using heat noxious stimuli either in intact or in injured animals after skin and muscular incisions. In the hot plate and in the plantar tests, nefopam after acute administration by different routes exhibited a dose-dependent attenuation of the nociceptive responses at 10-30 mg x kg(-1) by intraperitoneal or subcutaneous administration, at 60 mg x kg(-1) by oral dosing, and from 3 mg x kg(-1) after intravenous injection. In the postoperative pain model, at 30 mg x kg(-1) nefopam augmented the endpoint to thermal threshold, 60 and 90 minutes after administration compared to the threshold recorded after the incision. In the same conditions, morphine and tramadol displayed antinociceptive activities. As the plantar test provides a good index of nociception in humans, these results point out the usefulness of nefopam for attenuating moderate to severe pain, and for postoperative analgesia. In conclusion, nefopam has shown potent properties to reduce thermal hypersensitivity after acute or postoperative pain in rats.

Similar articles

See all similar articles

Cited by 12 PubMed Central articles

See all "Cited by" articles

LinkOut - more resources

Feedback