Pre-operative grading of intracranial glioma

Acta Radiol. 2001 Nov;42(6):548-54. doi: 10.1034/j.1600-0455.2001.420603.x.


Aim: To compare the accuracy of MR-determined cerebral blood volume (CBV) maps with SPECT imaging with thallium-201 in pre-operative grading of intracranial glioma.

Material and methods: Nineteen patients (7 female and 12 male, mean age 46.8 years) with intracranial gliomas were examined with MR perfusion imaging pre-operatively. Sixteen of these patients were also examined with SPECT imaging with thallium-201. The tumour to contralateral white matter NI (negative integral) and tracer uptake ratios were evaluated. The ratios in high-grade and low-grade tumours were compared.

Results: The maximum CBV ratios of grades I and II gliomas (2.958+/-2.217) were significantly lower than the maximum CBV ratio of grades III and IV (9.484+/-4.520), p<0.001. There was no statistical difference when CBV ratios of grades I and II (p=0.381), grades II and III (p=0.229) and grades III and IV (p=0.476) gliomas were compared. Thallium SPECT imaging showed no difference in tumour uptake ratio between low-grade and high-grade gliomas (p=0.299).

Conclusion: MR-determined NI was useful for pre-operative grading of intracranial gliomas but SPECT thallium-201 imaging was not.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Blood Volume / physiology*
  • Brain / diagnostic imaging
  • Brain / pathology
  • Brain / physiopathology
  • Brain Mapping
  • Brain Neoplasms / diagnostic imaging*
  • Brain Neoplasms / pathology*
  • Brain Neoplasms / physiopathology
  • Cerebrovascular Circulation / physiology
  • Female
  • Glioma / diagnostic imaging*
  • Glioma / pathology*
  • Glioma / physiopathology
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Preoperative Care
  • ROC Curve
  • Thallium Radioisotopes
  • Tomography, Emission-Computed, Single-Photon


  • Thallium Radioisotopes