Response of atypical symptoms of gastro-oesophageal reflux to antireflux surgery

Br J Surg. 2001 Dec;88(12):1649-52. doi: 10.1046/j.0007-1323.2001.01949.x.


Background: Atypical manifestations of gastro-oesophageal reflux (GOR) include asthma, chest pain, cough and hoarseness. The effectiveness of antireflux surgery for these symptoms is uncertain. The present study compared symptomatic response rates for typical and atypical GOR symptoms after fundoplication.

Methods: Between October 1991 and January 1998, 324 patients underwent laparoscopic fundoplication at Emory University Hospital and returned postoperative questionnaires. Severity of typical (heartburn) and atypical (asthma, chest pain, cough and hoarseness) GOR symptoms was reported by patients on a 0-4 scale before surgery, and at 6 and 52 weeks after operation. Patients were stratified based on preoperative symptoms into three groups: group 1 (severe heartburn/minimal atypical symptoms), group 2 (severe heartburn/severe atypical symptoms) and group 3 (minimal heartburn/severe atypical symptoms).

Results: In group 1 (n = 173) heartburn improved in 99 per cent and resolved in 87 per cent. In group 2 (n = 95) heartburn improved in 95 per cent and resolved in 76 per cent, and atypical symptoms improved in 94 per cent and resolved in 42 per cent. In group 3 (n = 56) atypical symptoms improved in 93 per cent and resolved in 48 per cent. Although all symptoms were improved by fundoplication, resolution was more likely for heartburn than for atypical symptoms.

Conclusion: Atypical symptoms of GOR are improved by fundoplication, but symptom resolution occurs in fewer than 50 per cent of patients.

MeSH terms

  • Asthma / etiology
  • Asthma / surgery
  • Chest Pain / etiology
  • Chest Pain / surgery
  • Cough / etiology
  • Cough / surgery
  • Female
  • Fundoplication / methods
  • Gastroesophageal Reflux / complications
  • Gastroesophageal Reflux / surgery*
  • Heartburn / etiology
  • Heartburn / surgery
  • Hoarseness / etiology
  • Hoarseness / surgery
  • Humans
  • Male
  • Middle Aged
  • Postoperative Period