Cutaneous sclerosing Pacinian-like perineurioma

Histopathology. 2001 Nov;39(5):498-502. doi: 10.1046/j.1365-2559.2001.01251.x.


Aims: The term perineurioma has been used to designate a variety of clinically and histologically different proliferations of perineurial cells based on immunohistochemical and/or ultrastructural characterization. There are two different groups of neoplasms derived from perineurial cells: extraneural or soft tissue perineuriomas, and intraneural perineuriomas. Recently, a sclerosing variant of cutaneous perineurioma has been described.

Methods and results: We report a case of a cutaneous form of perineurioma, combining features of the intraneural and sclerosing varieties, as well as showing a Pacinian pattern of growth. In order to assess the neoplastic nature of the lesion, we performed fluorescence in-situ hybridization (FISH) analysis using a probe which maps to the chromosome band 22q11 and 22q13, allowing us to show deletion or loss of one chromosome 22 in the tumour cells.

Conclusions: This case may be considered a new variant of perineurioma with Pacinian-like features, for which we propose the designation 'sclerosing Pacinian-like perineurioma'.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chromosome Aberrations
  • Chromosomes, Human, Pair 22 / genetics
  • Female
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization, Fluorescence
  • Mucin-1 / analysis
  • Nerve Sheath Neoplasms / genetics
  • Nerve Sheath Neoplasms / metabolism
  • Nerve Sheath Neoplasms / pathology*
  • Pacinian Corpuscles / pathology
  • Sclerosis / pathology
  • Skin Neoplasms / genetics
  • Skin Neoplasms / metabolism
  • Skin Neoplasms / pathology*
  • Vimentin / analysis


  • Mucin-1
  • Vimentin