Dbl Family Guanine Nucleotide Exchange Factors

Trends Biochem Sci. 2001 Dec;26(12):724-32. doi: 10.1016/s0968-0004(01)01973-9.

Abstract

The Dbl family of guanine nucleotide exchange factors are multifunctional molecules that transduce diverse intracellular signals leading to the activation of Rho GTPases. The tandem Dbl-homology and pleckstrin-homology domains shared by all members of this family represent the structural module responsible for catalyzing the GDP-GTP exchange reaction of Rho proteins. Recent progress in genomic, genetic, structural and biochemical studies has implicated Dbl family members in diverse biological processes, including growth and development, skeletal muscle formation, neuronal axon guidance and tissue organization. The detailed pictures of their autoregulation, agonist-controlled activation and mechanism of interaction with Rho GTPase substrates, have begun to emerge.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Evolution, Molecular
  • GTP-Binding Proteins / physiology
  • Guanine Nucleotide Exchange Factors / chemistry
  • Guanine Nucleotide Exchange Factors / physiology*
  • Humans
  • Models, Biological
  • Models, Molecular
  • Phosphatidylinositol 3-Kinases / physiology
  • Protein Kinases / physiology
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins / chemistry
  • Proto-Oncogene Proteins / physiology*
  • Signal Transduction
  • rho GTP-Binding Proteins / metabolism

Substances

  • Guanine Nucleotide Exchange Factors
  • MCF2 protein, human
  • Proto-Oncogene Proteins
  • Protein Kinases
  • Phosphatidylinositol 3-Kinases
  • GTP-Binding Proteins
  • rho GTP-Binding Proteins